Evidence Hub
(all articles below are freely available to view at the specified weblinks)

Articles from this research group

Walsh S, Govia I, Wallace L, Richard E, Peters R, Anstey K, Brayne C
Lancet Healthy Longevity, Jan 2022
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00301-9/fulltext
A summary of the rationale for population-level approaches to dementia risk reduction from the founding members of this research group. Includes direct comparisons of what individual-level and population-level policies against each of the modifiable risk factors can look like.
Transcript of the IRNDP Symposium at ADI 2022
Walsh S, Anstey K, Peters R, Wilson N-A, Lin F, Stephan B, Richard E, Govia I, Brayne C
Embed the PDF? (ready for upload to website in next few days, not planned for publication) – or we can upload to a separate IRNDP webpage and link across here.
This is a summary of the key points raised at the symposium sponsored by IRNDP at ADI 2022 entitled: ‘What do we mean by population-based approaches to dementia risk reduction?’, held on the 10th of June 2022.
Alzheimer’s Disease International, May 2022
https://www.alzint.org/u/From-Plan-to-Impact-V.pdf
The chapter on risk reduction (chapter 3), of this major global report on dementia research, opens with an essay from members of the PLADRR research group. The essay explains the importance of population-level approaches to dementia risk reduction, and explores how we might apply such approaches moving forwards.

Related literature

Wolters F, Chibnik L, Waziry R et al. Neurology, August 2020
https://n.neurology.org/content/neurology/95/5/e519.full.pdf
This pooled analysis of several cohorts across Europe and the USA shows that dementia incidence rate declined by 13% over the preceding 25 years. This is a key finding that indicates dementia risk can be reduced at a population level.
Livingston G, Huntley J, Sommerlad A et al.
The Lancet, July 2020
https://www.thelancet.com/article/S0140-6736(20)30367-6/fulltext
This widely cited review includes identification of 12 potentially modifiable risk factors for dementia: education, hearing loss, traumatic brain injury, hypertension, excess alcohol, obesity, smoking, depression, social isolation, physical inactivity, air pollution, and diabetes. Combined, these factors could account for up to 40% of dementia worldwide (a higher proportion in resource-constrained settings).
The World Health Organization, 2017
https://apps.who.int/iris/handle/10665/259232
In this document, the World Health Organization summarise the interventions which have the best evidence for being cost-effective for the protection of non-communicable diseases. Though dementia itself is not a direct target of this work, several of the proposed modifiable risk factors from the Lancet Commission (including: obesity, physical inactivity, smoking, excess alcohol, diabetes, and hypertension) are directly considered here. The majority of the interventions labelled as ‘best buys’ are population-level interventions.

Upcoming papers from members of this research group