Evidence hub – evidence synthesis

The evidence synthesis group brings together researchers and academics to collaborate, share expertise and generate high quality systematic reviews and meta-analyses relating to dementia, its prevention or delay.


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IRNDP Evidence Synthesis Work

Our systematic reviews and meta-analyses relate to multiple risk factors for incident dementia, potential interventions and methodologies used for cognitive assessment.

Over 20 systematic reviews published

  • Including systematic reviews on smoking, cholesterol and alcohol
  • Highly cited in the scientific literature
  • Cited in clinical guidelines and public and patient facing information sources

Consensus documents and guidelines citing our work:

  • The 2014 World Alzheimer report
  • World Health Organisation knowledge summaries
  • The UK Blackfriars Consensus
  • The BMJ best practice guide

We are keen to ensure that our work translates into clinical practice where possible and always raises new questions, highlights gaps in the evidence base and signposts the key directions for future research.

Examples of our work:

Peters R, Peters J, Booth A, Mudway I,. Does air pollution increase the risk of cognitive decline? A systematic review . Age Ageing 2015 doi: 10.1093/ageing/afv087

Clifford, A, Lang, L, Chen, R et al 2016, 'Exposure to air pollution and cognitive functioning across the life course - A systematic literature review', Environmental Research, vol. 147, pp. 383-398.

Peters, R., Ee, N., Peters, J., Booth, A., Mudway, I., & Anstey, K. J. (2019). Air Pollution and Dementia: A Systematic Review. Journal of Alzheimer's Disease, (Preprint), 1-19.
Anstey, K, Mack, H & Cherbuin, N 2009, 'Alcohol Consumption as a Risk Factor for Dementia and Cognitive Decline:A Meta-Analysis of Prospective Studies', American Journal of Geriatric Psychiatry, vol. 17, no. 7, pp. 542-555.

Peters R, Peters J, Warner J, Beckett N, Bulpitt C. Alcohol, dementia and cognitive decline in the elderly: a systematic review. Age Ageing 2008; 37: 505-512
Anstey, KJ, Cherbuin, N, Budge, M et al 2011, 'Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies', Obesity Reviews, vol. 12, no. 5, pp. 12 pp.

Pedditzi E, Peters R, Beckett N. The risk of overweight/obesity in midlife and late life for the development of dementia: systematic review and meta-analysis of longitudinal studies. Age Ageing 2016; 45(1):14-21

Danat, I. M., Clifford, A., Partridge, M., Zhou, W., Bakre, A. T., Chen, A., ... & Anstey, K. J. (2019). Impacts of Overweight and Obesity in Older Age on the Risk of Dementia: A Systematic Literature Review and a Meta-Analysis. Journal of Alzheimer's Disease, (Preprint), 1-13.
Anstey, K, Lipnicki, D & Low, L 2008, 'Cholesterol as a risk factor for dementia and cognitive decline: A systematic review of prospective studies with Meta- Analysis', American Journal of Geriatric Psychiatry, vol. 16, no. 5, pp. 343 -354. https://www.ncbi.nlm.nih.gov/pubmed/18448847

Anstey, K. J., Ashby-Mitchell, K., & Peters, R. (2017). Updating the evidence on the association between serum cholesterol and risk of late-life dementia: review and meta-analysis. Journal of Alzheimer's Disease56(1), 215-228. https://www.ncbi.nlm.nih.gov/pubmed/27911314 
Cherbuin, N, Kim, S & Anstey, K 2015, 'Dementia risk estimates associated with measures of depression: A systematic review and meta-analysis', BMJ Open, vol. 5, no. 12, pp. -.
Peters R, Burch L, Warner J, Beckett N, Poulter R, Bulpitt C. Haemoglobin, anaemia, dementia and cognitive decline in the elderly, a systematic review, BMC Geriatrics 2008; 8: 18. 8 Aug 08
Yasar S, Schuchman M, Peters J, Anstey KJ, Carlson MC, Peters R.Relationship Between Antihypertensive Medications and Cognitive Impairment: Part I. Review of Human Studies and Clinical Trials. Curr Hypertens Rep. 2016 Aug;18(8):67. doi: 10.1007/s11906-016-0674-1.

Peters R, Schuchman M, Peters J, Carlson MC, Yasar S.Relationship Between Antihypertensive Medications and Cognitive Impairment: Part II. Review of Physiology and Animal Studies. Curr Hypertens Rep. 2016 Aug;18(8):66. doi: 10.1007/s11906-016-0673-2.

Peters R, Booth A, Peters J. A systematic review of Calcium Channel Blocker use and cognitive decline/dementia in the elderly Journal of Hypertension 2014 32(10) 1945-1958 https://www.ncbi.nlm.nih.gov/pubmed/25068540
Hosking D, Ayton S, Beckett N, Booth A, Peters R. More evidence is needed. Iron, incident cognitive decline and dementia: a systematic review, Therapeutic Advances in Chronic Disease 2018 doi.org/10.1177/2040622318788485.
Chen, R, Clifford, A, Lang, L et al 2013, 'Is exposure to second-hand smoke associated with cognitive parameters of children and adolescents? - a systematic literature review', Annals of Epidemiology, vol. 23, no. 10, pp. 652e661.
Anstey, K, Von Sanden, C, Salim, A et al 2007, 'Smoking as a Risk Factor for Dementia and Cognitive Decline : A Meta- Analysis of Prospective Studies', American Journal of Epidemiology, vol. 166, no. 4, pp. 367-378.

Peters R, Poulter R, Warner J, Beckett N, Burch, L, Bulpitt C. Smoking, dementia and cognitive decline in the elderly, a systematic review, BMC Geriatrics 2008 8;36 DOI 10.1186/1471-2318-8-36.
Evans, I. E., Martyr, A., Collins, R., Brayne, C., & Clare, L. (2018). Social isolation and cognitive function in later life: A systematic review and meta-analysis. Journal of Alzheimer's Disease, (Preprint), 1-26.
Peters, R., Booth, A., Rockwood, K., Peters, J., D’Este, C., & Anstey, K. J. (2019). Combining modifiable risk factors and risk of dementia: a systematic review and meta-analysis. BMJ Open, 9(1), bmjopen-2018.
Anstey KJ, Ee N, Eramudugolla R, Jagger C, Peters R. A Systematic Review of Meta-Analyses that Evaluate Risk Factors for Dementia to Evaluate the Quantity, Quality, and Global Representativeness of Evidence. Journal of Alzheimer's disease : JAD. 2019;70(s1):S165-s186.

We combine our expertise in different ways carrying our reviews and analyses centrally or separately for each study. We very much welcome new members. If you are interested in joining please contact us.

Terms and conditions

The recommendations, views or findings expressed in studies, trials or articles are expressly those of the authors. Such recommendations, views or findings do not represent the recommendations, views or findings of the International Research Network on Dementia Prevention (IRNDP), its Leadership Committee or Independent Advisory Group or any collaborating institutions. IRNDP accepts no responsibility for the accuracy or content, or liability in respect of studies submitted to it.